Late Consequences of Acute Coronary Syndromes: Global Registry of Acute Coronary Events (GRACE) Follow-up.
Identifieur interne : 002B59 ( PubMed/Curation ); précédent : 002B58; suivant : 002B60Late Consequences of Acute Coronary Syndromes: Global Registry of Acute Coronary Events (GRACE) Follow-up.
Auteurs : Sami M A. Alnasser [Arabie saoudite] ; Wei Huang ; Joel M. Gore ; Ph Gabriel Steg [France] ; Kim A. Eagle ; Frederick A. Anderson ; Keith A A. Fox [Royaume-Uni] ; Enrique Gurfinkel [Argentine] ; David Brieger [Australie] ; Werner Klein [Autriche] ; Frans Van De Werf [Belgique] ; Álvaro Avezum [Brésil] ; Gilles Montalescot [France] ; Dietrich C. Gulba [Allemagne] ; Andrzej Budaj [Pologne] ; Jose Lopez-Sendon [Espagne] ; Christopher B. Granger [États-Unis] ; Brian M. Kennelly ; Robert J. Goldberg ; Emily Fleming [Canada] ; Shaun G. Goodman [Canada]Source :
- The American journal of medicine [ 1555-7162 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Analyse de survie, Angioplastie coronaire par ballonnet (), Angioplastie coronaire par ballonnet (mortalité), Cause de décès, Continuité des soins, Enregistrements, Facteurs temps, Femelle, Humains, Indice de gravité médicale, Internationalité, Mortalité hospitalière, Mâle, Pontage aortocoronarien (), Pontage aortocoronarien (mortalité), Répartition par sexe, Répartition par âge, Résultat thérapeutique, Santé mondiale, Sortie du patient (), Sujet âgé, Syndrome coronarien aigu (), Syndrome coronarien aigu (diagnostic), Syndrome coronarien aigu (épidémiologie), Études de suivi, Études rétrospectives, Évaluation des risques.
- MESH :
- diagnostic : Syndrome coronarien aigu.
- mortalité : Angioplastie coronaire par ballonnet, Pontage aortocoronarien.
- épidémiologie : Syndrome coronarien aigu.
- Adulte d'âge moyen, Analyse de survie, Angioplastie coronaire par ballonnet, Cause de décès, Continuité des soins, Enregistrements, Facteurs temps, Femelle, Humains, Indice de gravité médicale, Internationalité, Mortalité hospitalière, Mâle, Pontage aortocoronarien, Répartition par sexe, Répartition par âge, Résultat thérapeutique, Santé mondiale, Sortie du patient, Sujet âgé, Syndrome coronarien aigu, Études de suivi, Études rétrospectives, Évaluation des risques.
English descriptors
- KwdEn :
- Acute Coronary Syndrome (diagnosis), Acute Coronary Syndrome (epidemiology), Acute Coronary Syndrome (therapy), Age Distribution, Aged, Angioplasty, Balloon, Coronary (methods), Angioplasty, Balloon, Coronary (mortality), Cause of Death, Continuity of Patient Care, Coronary Artery Bypass (methods), Coronary Artery Bypass (mortality), Female, Follow-Up Studies, Global Health, Hospital Mortality, Humans, Internationality, Male, Middle Aged, Patient Discharge (statistics & numerical data), Registries, Retrospective Studies, Risk Assessment, Severity of Illness Index, Sex Distribution, Survival Analysis, Time Factors, Treatment Outcome.
- MESH :
- diagnosis : Acute Coronary Syndrome.
- epidemiology : Acute Coronary Syndrome.
- methods : Angioplasty, Balloon, Coronary, Coronary Artery Bypass.
- mortality : Angioplasty, Balloon, Coronary, Coronary Artery Bypass.
- statistics & numerical data : Patient Discharge.
- therapy : Acute Coronary Syndrome.
- Age Distribution, Aged, Cause of Death, Continuity of Patient Care, Female, Follow-Up Studies, Global Health, Hospital Mortality, Humans, Internationality, Male, Middle Aged, Registries, Retrospective Studies, Risk Assessment, Severity of Illness Index, Sex Distribution, Survival Analysis, Time Factors, Treatment Outcome.
Abstract
Short-term outcomes have been well characterized in acute coronary syndromes; however, longer-term follow-up for the entire spectrum of these patients, including ST-segment-elevation myocardial infarction, non-ST-segment-elevation myocardial infarction, and unstable angina, is more limited. Therefore, we describe the longer-term outcomes, procedures, and medication use in Global Registry of Acute Coronary Events (GRACE) hospital survivors undergoing 6-month and 2-year follow-up, and the performance of the discharge GRACE risk score in predicting 2-year mortality.
DOI: 10.1016/j.amjmed.2014.12.007
PubMed: 25554379
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Wei Huang<affiliation><nlm:affiliation>Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester.</nlm:affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester.</nlm:affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation><affiliation><nlm:affiliation>University of Michigan Health System, Ann Arbor.</nlm:affiliation><wicri:noCountry code="subField">Ann Arbor</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Center for Outcomes Research, University of Massachusetts Medical School, Worcester.</nlm:affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Hoag Memorial Hospital Presbyterian, Newport Beach, Calif.</nlm:affiliation><wicri:noCountry code="subField">Calif</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Division of Epidemiology of Chronic Diseases and Vulnerable Populations, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester.</nlm:affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation>Le document en format XML
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Alnasser</name><affiliation wicri:level="1"><nlm:affiliation>Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Ont., Canada; King Fahad Cardiac Center, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Ont., Canada; King Fahad Cardiac Center, King Saud University, Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Wei" sort="Huang, Wei" uniqKey="Huang W" first="Wei" last="Huang">Wei Huang</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester.</nlm:affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation></author><author><name sortKey="Gore, Joel M" sort="Gore, Joel M" uniqKey="Gore J" first="Joel M" last="Gore">Joel M. 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Fox</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cardiovascular Science, University of Edinburgh, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Science, University of Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Gurfinkel, Enrique" sort="Gurfinkel, Enrique" uniqKey="Gurfinkel E" first="Enrique" last="Gurfinkel">Enrique Gurfinkel</name><affiliation wicri:level="1"><nlm:affiliation>ICYCC Favaloro Foundation, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>ICYCC Favaloro Foundation, Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Brieger, David" sort="Brieger, David" uniqKey="Brieger D" first="David" last="Brieger">David Brieger</name><affiliation wicri:level="1"><nlm:affiliation>Concord Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Concord Hospital and University of Sydney, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Werner" sort="Klein, Werner" uniqKey="Klein W" first="Werner" last="Klein">Werner Klein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Krankenhaus der Barmherzigen Bruder, Teaching Hospital of the Karl Franzens University Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine, Krankenhaus der Barmherzigen Bruder, Teaching Hospital of the Karl Franzens University Graz, Graz</wicri:regionArea></affiliation></author><author><name sortKey="Van De Werf, Frans" sort="Van De Werf, Frans" uniqKey="Van De Werf F" first="Frans" last="Van De Werf">Frans Van De Werf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Cardiovascular Medicine, University Hospitals Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Avezum, Alvaro" sort="Avezum, Alvaro" uniqKey="Avezum A" first="Álvaro" last="Avezum">Álvaro Avezum</name><affiliation wicri:level="1"><nlm:affiliation>Dante Pazzanese Institute of Cardiology, São Paulo, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Dante Pazzanese Institute of Cardiology, São Paulo, SP</wicri:regionArea></affiliation></author><author><name sortKey="Montalescot, Gilles" sort="Montalescot, Gilles" uniqKey="Montalescot G" first="Gilles" last="Montalescot">Gilles Montalescot</name><affiliation wicri:level="1"><nlm:affiliation>Institut de Cardiologie, Centre Hospitalier Universitaire Pitié-Salpêtrière (AP-HP), Univ Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Cardiologie, Centre Hospitalier Universitaire Pitié-Salpêtrière (AP-HP), Univ Paris 06, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Gulba, Dietrich C" sort="Gulba, Dietrich C" uniqKey="Gulba D" first="Dietrich C" last="Gulba">Dietrich C. Gulba</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, KKO St. Marien-Hospital, Oberhausen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, KKO St. Marien-Hospital, Oberhausen</wicri:regionArea></affiliation></author><author><name sortKey="Budaj, Andrzej" sort="Budaj, Andrzej" uniqKey="Budaj A" first="Andrzej" last="Budaj">Andrzej Budaj</name><affiliation wicri:level="1"><nlm:affiliation>Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Postgraduate Medical School, Grochowski Hospital, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Lopez Sendon, Jose" sort="Lopez Sendon, Jose" uniqKey="Lopez Sendon J" first="Jose" last="Lopez-Sendon">Jose Lopez-Sendon</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario La Paz, Instituto de Investigación La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario La Paz, Instituto de Investigación La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Granger, Christopher B" sort="Granger, Christopher B" uniqKey="Granger C" first="Christopher B" last="Granger">Christopher B. Granger</name><affiliation wicri:level="2"><nlm:affiliation>Duke Clinical Research Institute, Duke University Medical Center, Durham, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Duke Clinical Research Institute, Duke University Medical Center, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Kennelly, Brian M" sort="Kennelly, Brian M" uniqKey="Kennelly B" first="Brian M" last="Kennelly">Brian M. Kennelly</name><affiliation><nlm:affiliation>Hoag Memorial Hospital Presbyterian, Newport Beach, Calif.</nlm:affiliation><wicri:noCountry code="subField">Calif</wicri:noCountry></affiliation></author><author><name sortKey="Goldberg, Robert J" sort="Goldberg, Robert J" uniqKey="Goldberg R" first="Robert J" last="Goldberg">Robert J. Goldberg</name><affiliation><nlm:affiliation>Division of Epidemiology of Chronic Diseases and Vulnerable Populations, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester.</nlm:affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation></author><author><name sortKey="Fleming, Emily" sort="Fleming, Emily" uniqKey="Fleming E" first="Emily" last="Fleming">Emily Fleming</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Heart Research Centre, Toronto, Ont., Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Heart Research Centre, Toronto, Ont.</wicri:regionArea></affiliation></author><author><name sortKey="Goodman, Shaun G" sort="Goodman, Shaun G" uniqKey="Goodman S" first="Shaun G" last="Goodman">Shaun G. Goodman</name><affiliation wicri:level="1"><nlm:affiliation>Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Ont., Canada; Canadian Heart Research Centre, Toronto, Ont., Canada. Electronic address: goodmans@smh.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Ont., Canada; Canadian Heart Research Centre, Toronto, Ont.</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25554379</idno><idno type="pmid">25554379</idno><idno type="doi">10.1016/j.amjmed.2014.12.007</idno><idno type="wicri:Area/PubMed/Corpus">002C32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002C32</idno><idno type="wicri:Area/PubMed/Curation">002B59</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B59</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Late Consequences of Acute Coronary Syndromes: Global Registry of Acute Coronary Events (GRACE) Follow-up.</title><author><name sortKey="Alnasser, Sami M A" sort="Alnasser, Sami M A" uniqKey="Alnasser S" first="Sami M A" last="Alnasser">Sami M A. Alnasser</name><affiliation wicri:level="1"><nlm:affiliation>Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Ont., Canada; King Fahad Cardiac Center, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Ont., Canada; King Fahad Cardiac Center, King Saud University, Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Wei" sort="Huang, Wei" uniqKey="Huang W" first="Wei" last="Huang">Wei Huang</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester.</nlm:affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation></author><author><name sortKey="Gore, Joel M" sort="Gore, Joel M" uniqKey="Gore J" first="Joel M" last="Gore">Joel M. Gore</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester.</nlm:affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation></author><author><name sortKey="Steg, Ph Gabriel" sort="Steg, Ph Gabriel" uniqKey="Steg P" first="Ph Gabriel" last="Steg">Ph Gabriel Steg</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U-698, Université Paris 7, Centre Hospitalier Bichat-Claude Bernard, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U-698, Université Paris 7, Centre Hospitalier Bichat-Claude Bernard, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Eagle, Kim A" sort="Eagle, Kim A" uniqKey="Eagle K" first="Kim A" last="Eagle">Kim A. Eagle</name><affiliation><nlm:affiliation>University of Michigan Health System, Ann Arbor.</nlm:affiliation><wicri:noCountry code="subField">Ann Arbor</wicri:noCountry></affiliation></author><author><name sortKey="Anderson, Frederick A" sort="Anderson, Frederick A" uniqKey="Anderson F" first="Frederick A" last="Anderson">Frederick A. Anderson</name><affiliation><nlm:affiliation>Center for Outcomes Research, University of Massachusetts Medical School, Worcester.</nlm:affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation></author><author><name sortKey="Fox, Keith A A" sort="Fox, Keith A A" uniqKey="Fox K" first="Keith A A" last="Fox">Keith A A. Fox</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cardiovascular Science, University of Edinburgh, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Science, University of Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Gurfinkel, Enrique" sort="Gurfinkel, Enrique" uniqKey="Gurfinkel E" first="Enrique" last="Gurfinkel">Enrique Gurfinkel</name><affiliation wicri:level="1"><nlm:affiliation>ICYCC Favaloro Foundation, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>ICYCC Favaloro Foundation, Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Brieger, David" sort="Brieger, David" uniqKey="Brieger D" first="David" last="Brieger">David Brieger</name><affiliation wicri:level="1"><nlm:affiliation>Concord Hospital and University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Concord Hospital and University of Sydney, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Werner" sort="Klein, Werner" uniqKey="Klein W" first="Werner" last="Klein">Werner Klein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Krankenhaus der Barmherzigen Bruder, Teaching Hospital of the Karl Franzens University Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine, Krankenhaus der Barmherzigen Bruder, Teaching Hospital of the Karl Franzens University Graz, Graz</wicri:regionArea></affiliation></author><author><name sortKey="Van De Werf, Frans" sort="Van De Werf, Frans" uniqKey="Van De Werf F" first="Frans" last="Van De Werf">Frans Van De Werf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Cardiovascular Medicine, University Hospitals Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Avezum, Alvaro" sort="Avezum, Alvaro" uniqKey="Avezum A" first="Álvaro" last="Avezum">Álvaro Avezum</name><affiliation wicri:level="1"><nlm:affiliation>Dante Pazzanese Institute of Cardiology, São Paulo, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Dante Pazzanese Institute of Cardiology, São Paulo, SP</wicri:regionArea></affiliation></author><author><name sortKey="Montalescot, Gilles" sort="Montalescot, Gilles" uniqKey="Montalescot G" first="Gilles" last="Montalescot">Gilles Montalescot</name><affiliation wicri:level="1"><nlm:affiliation>Institut de Cardiologie, Centre Hospitalier Universitaire Pitié-Salpêtrière (AP-HP), Univ Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Cardiologie, Centre Hospitalier Universitaire Pitié-Salpêtrière (AP-HP), Univ Paris 06, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Gulba, Dietrich C" sort="Gulba, Dietrich C" uniqKey="Gulba D" first="Dietrich C" last="Gulba">Dietrich C. Gulba</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, KKO St. Marien-Hospital, Oberhausen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, KKO St. Marien-Hospital, Oberhausen</wicri:regionArea></affiliation></author><author><name sortKey="Budaj, Andrzej" sort="Budaj, Andrzej" uniqKey="Budaj A" first="Andrzej" last="Budaj">Andrzej Budaj</name><affiliation wicri:level="1"><nlm:affiliation>Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Postgraduate Medical School, Grochowski Hospital, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Lopez Sendon, Jose" sort="Lopez Sendon, Jose" uniqKey="Lopez Sendon J" first="Jose" last="Lopez-Sendon">Jose Lopez-Sendon</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario La Paz, Instituto de Investigación La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario La Paz, Instituto de Investigación La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Granger, Christopher B" sort="Granger, Christopher B" uniqKey="Granger C" first="Christopher B" last="Granger">Christopher B. Granger</name><affiliation wicri:level="2"><nlm:affiliation>Duke Clinical Research Institute, Duke University Medical Center, Durham, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Duke Clinical Research Institute, Duke University Medical Center, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Kennelly, Brian M" sort="Kennelly, Brian M" uniqKey="Kennelly B" first="Brian M" last="Kennelly">Brian M. Kennelly</name><affiliation><nlm:affiliation>Hoag Memorial Hospital Presbyterian, Newport Beach, Calif.</nlm:affiliation><wicri:noCountry code="subField">Calif</wicri:noCountry></affiliation></author><author><name sortKey="Goldberg, Robert J" sort="Goldberg, Robert J" uniqKey="Goldberg R" first="Robert J" last="Goldberg">Robert J. Goldberg</name><affiliation><nlm:affiliation>Division of Epidemiology of Chronic Diseases and Vulnerable Populations, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester.</nlm:affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation></author><author><name sortKey="Fleming, Emily" sort="Fleming, Emily" uniqKey="Fleming E" first="Emily" last="Fleming">Emily Fleming</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Heart Research Centre, Toronto, Ont., Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Heart Research Centre, Toronto, Ont.</wicri:regionArea></affiliation></author><author><name sortKey="Goodman, Shaun G" sort="Goodman, Shaun G" uniqKey="Goodman S" first="Shaun G" last="Goodman">Shaun G. Goodman</name><affiliation wicri:level="1"><nlm:affiliation>Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Ont., Canada; Canadian Heart Research Centre, Toronto, Ont., Canada. Electronic address: goodmans@smh.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Ont., Canada; Canadian Heart Research Centre, Toronto, Ont.</wicri:regionArea></affiliation></author></analytic><series><title level="j">The American journal of medicine</title><idno type="eISSN">1555-7162</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Coronary Syndrome (diagnosis)</term><term>Acute Coronary Syndrome (epidemiology)</term><term>Acute Coronary Syndrome (therapy)</term><term>Age Distribution</term><term>Aged</term><term>Angioplasty, Balloon, Coronary (methods)</term><term>Angioplasty, Balloon, Coronary (mortality)</term><term>Cause of Death</term><term>Continuity of Patient Care</term><term>Coronary Artery Bypass (methods)</term><term>Coronary Artery Bypass (mortality)</term><term>Female</term><term>Follow-Up Studies</term><term>Global Health</term><term>Hospital Mortality</term><term>Humans</term><term>Internationality</term><term>Male</term><term>Middle Aged</term><term>Patient Discharge (statistics & numerical data)</term><term>Registries</term><term>Retrospective Studies</term><term>Risk Assessment</term><term>Severity of Illness Index</term><term>Sex Distribution</term><term>Survival Analysis</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de survie</term><term>Angioplastie coronaire par ballonnet ()</term><term>Angioplastie coronaire par ballonnet (mortalité)</term><term>Cause de décès</term><term>Continuité des soins</term><term>Enregistrements</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Internationalité</term><term>Mortalité hospitalière</term><term>Mâle</term><term>Pontage aortocoronarien ()</term><term>Pontage aortocoronarien (mortalité)</term><term>Répartition par sexe</term><term>Répartition par âge</term><term>Résultat thérapeutique</term><term>Santé mondiale</term><term>Sortie du patient ()</term><term>Sujet âgé</term><term>Syndrome coronarien aigu ()</term><term>Syndrome coronarien aigu (diagnostic)</term><term>Syndrome coronarien aigu (épidémiologie)</term><term>Études de suivi</term><term>Études rétrospectives</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Acute Coronary Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome coronarien aigu</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Acute Coronary Syndrome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Angioplasty, Balloon, Coronary</term><term>Coronary Artery Bypass</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Angioplasty, Balloon, Coronary</term><term>Coronary Artery Bypass</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Angioplastie coronaire par ballonnet</term><term>Pontage aortocoronarien</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Patient Discharge</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Acute Coronary Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Syndrome coronarien aigu</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Distribution</term><term>Aged</term><term>Cause of Death</term><term>Continuity of Patient Care</term><term>Female</term><term>Follow-Up Studies</term><term>Global Health</term><term>Hospital Mortality</term><term>Humans</term><term>Internationality</term><term>Male</term><term>Middle Aged</term><term>Registries</term><term>Retrospective Studies</term><term>Risk Assessment</term><term>Severity of Illness Index</term><term>Sex Distribution</term><term>Survival Analysis</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de survie</term><term>Angioplastie coronaire par ballonnet</term><term>Cause de décès</term><term>Continuité des soins</term><term>Enregistrements</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Internationalité</term><term>Mortalité hospitalière</term><term>Mâle</term><term>Pontage aortocoronarien</term><term>Répartition par sexe</term><term>Répartition par âge</term><term>Résultat thérapeutique</term><term>Santé mondiale</term><term>Sortie du patient</term><term>Sujet âgé</term><term>Syndrome coronarien aigu</term><term>Études de suivi</term><term>Études rétrospectives</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Short-term outcomes have been well characterized in acute coronary syndromes; however, longer-term follow-up for the entire spectrum of these patients, including ST-segment-elevation myocardial infarction, non-ST-segment-elevation myocardial infarction, and unstable angina, is more limited. Therefore, we describe the longer-term outcomes, procedures, and medication use in Global Registry of Acute Coronary Events (GRACE) hospital survivors undergoing 6-month and 2-year follow-up, and the performance of the discharge GRACE risk score in predicting 2-year mortality.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25554379</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>20</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>25</Day></DateCompleted><DateRevised><Year>2015</Year><Month>06</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1555-7162</ISSN><JournalIssue CitedMedium="Internet"><Volume>128</Volume><Issue>7</Issue><PubDate><Year>2015</Year><Month>Jul</Month></PubDate></JournalIssue><Title>The American journal of medicine</Title><ISOAbbreviation>Am. J. Med.</ISOAbbreviation></Journal><ArticleTitle>Late Consequences of Acute Coronary Syndromes: Global Registry of Acute Coronary Events (GRACE) Follow-up.</ArticleTitle><Pagination><MedlinePgn>766-75</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.amjmed.2014.12.007</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0002-9343(14)01225-X</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Short-term outcomes have been well characterized in acute coronary syndromes; however, longer-term follow-up for the entire spectrum of these patients, including ST-segment-elevation myocardial infarction, non-ST-segment-elevation myocardial infarction, and unstable angina, is more limited. Therefore, we describe the longer-term outcomes, procedures, and medication use in Global Registry of Acute Coronary Events (GRACE) hospital survivors undergoing 6-month and 2-year follow-up, and the performance of the discharge GRACE risk score in predicting 2-year mortality.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Between 1999 and 2007, 70,395 patients with a suspected acute coronary syndrome were enrolled. In 2004, 2-year prospective follow-up was undertaken in those with a discharge acute coronary syndrome diagnosis in 57 sites.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">From 2004 to 2007, 19,122 (87.2%) patients underwent follow-up; by 2 years postdischarge, 14.3% underwent angiography, 8.7% percutaneous coronary intervention, 2.0% coronary bypass surgery, and 24.2% were re-hospitalized. In patients with 2-year follow-up, acetylsalicylic acid (88.7%), beta-blocker (80.4%), renin-angiotensin system inhibitor (69.8%), and statin (80.2%) therapy was used. Heart failure occurred in 6.3%, (re)infarction in 4.4%, and death in 7.1%. Discharge-to-6-month GRACE risk score was highly predictive of all-cause mortality at 2 years (c-statistic 0.80).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In this large multinational cohort of acute coronary syndrome patients, there were important later adverse consequences, including frequent morbidity and mortality. These findings were seen in the context of additional coronary procedures and despite continued use of evidence-based therapies in a high proportion of patients. The discriminative accuracy of the GRACE risk score in hospital survivors for predicting longer-term mortality was maintained.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Alnasser</LastName><ForeName>Sami M A</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Ont., Canada; King Fahad Cardiac Center, King Saud University, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gore</LastName><ForeName>Joel M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steg</LastName><ForeName>Ph Gabriel</ForeName><Initials>PG</Initials><AffiliationInfo><Affiliation>INSERM U-698, Université Paris 7, Centre Hospitalier Bichat-Claude Bernard, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eagle</LastName><ForeName>Kim A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>University of Michigan Health System, Ann Arbor.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Frederick A</ForeName><Initials>FA</Initials><Suffix>Jr</Suffix><AffiliationInfo><Affiliation>Center for Outcomes Research, University of Massachusetts Medical School, Worcester.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fox</LastName><ForeName>Keith A A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Science, University of Edinburgh, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gurfinkel</LastName><ForeName>Enrique</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>ICYCC Favaloro Foundation, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brieger</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Concord Hospital and University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klein</LastName><ForeName>Werner</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Krankenhaus der Barmherzigen Bruder, Teaching Hospital of the Karl Franzens University Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van de Werf</LastName><ForeName>Frans</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Avezum</LastName><ForeName>Álvaro</ForeName><Initials>Á</Initials><AffiliationInfo><Affiliation>Dante Pazzanese Institute of Cardiology, São Paulo, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montalescot</LastName><ForeName>Gilles</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institut de Cardiologie, Centre Hospitalier Universitaire Pitié-Salpêtrière (AP-HP), Univ Paris 06, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gulba</LastName><ForeName>Dietrich C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Department of Cardiology, KKO St. Marien-Hospital, Oberhausen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Budaj</LastName><ForeName>Andrzej</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lopez-Sendon</LastName><ForeName>Jose</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hospital Universitario La Paz, Instituto de Investigación La Paz, IdiPaz, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Granger</LastName><ForeName>Christopher B</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>Duke Clinical Research Institute, Duke University Medical Center, Durham, NC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kennelly</LastName><ForeName>Brian M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Hoag Memorial Hospital Presbyterian, Newport Beach, Calif.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goldberg</LastName><ForeName>Robert J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Division of Epidemiology of Chronic Diseases and Vulnerable Populations, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fleming</LastName><ForeName>Emily</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Canadian Heart Research Centre, Toronto, Ont., Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goodman</LastName><ForeName>Shaun G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Ont., Canada; Canadian Heart Research Centre, Toronto, Ont., Canada. Electronic address: goodmans@smh.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>GRACE Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>12</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Med</MedlineTA><NlmUniqueID>0267200</NlmUniqueID><ISSNLinking>0002-9343</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D054058" MajorTopicYN="N">Acute Coronary Syndrome</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017677" MajorTopicYN="N">Age Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015906" MajorTopicYN="N">Angioplasty, Balloon, Coronary</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002423" MajorTopicYN="Y">Cause of Death</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003266" MajorTopicYN="N">Continuity of Patient Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001026" MajorTopicYN="N">Coronary Artery Bypass</DescriptorName><QualifierName 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MajorTopicYN="N">Patient Discharge</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012042" MajorTopicYN="Y">Registries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017678" MajorTopicYN="N">Sex Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute coronary syndromes</Keyword><Keyword MajorTopicYN="N">Coronary revascularization</Keyword><Keyword MajorTopicYN="N">Prognosis</Keyword><Keyword MajorTopicYN="N">Risk stratification</Keyword></KeywordList><InvestigatorList><Investigator ValidYN="Y"><LastName>Gurfinkel</LastName><ForeName>Enrique</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Caridi</LastName><ForeName>Maria</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Budassi</LastName><ForeName>Nadia</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Waites</LastName><ForeName>Jon</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Counsell</LastName><ForeName>John</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Juergens</LastName><ForeName>Craig</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brieger</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lefkovits</LastName><ForeName>Jeffrey</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gaul</LastName><ForeName>Georg</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Simader</LastName><ForeName>Harald</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Schellnegger</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials></Investigator><Investigator ValidYN="Y"><LastName>Van de Werf</LastName><ForeName>Frans</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Coussement</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Henuzet</LastName><ForeName>Charles</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Renard</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Quiñonez</LastName><ForeName>Manuel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>De Raedt</LastName><ForeName>Herbert</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marino</LastName><ForeName>Roberto</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carvalho</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Timerman</LastName><ForeName>Ari</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Albuquerque</LastName><ForeName>Denilson</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Coutinho</LastName><ForeName>Mario</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Esteves</LastName><ForeName>José</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Maia</LastName><ForeName>Lília Nigro</ForeName><Initials>LN</Initials></Investigator><Investigator ValidYN="Y"><LastName>Goodman</LastName><ForeName>Shaun</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cha</LastName><ForeName>James</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>DeVilla</LastName><ForeName>Maria</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Leader</LastName><ForeName>Roland</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chetty</LastName><ForeName>Rajen</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Spencer</LastName><ForeName>Frederick</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Montalescot</LastName><ForeName>Gilles</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Steg</LastName><ForeName>Ph Gabriel</ForeName><Initials>PG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ohlmeier</LastName><ForeName>Harm</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Devlin</LastName><ForeName>Gerard</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Elliott</LastName><ForeName>John</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Budaj</LastName><ForeName>Andrzej</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Krasowski</LastName><ForeName>Wlodzimierz</ForeName><Initials>W</Initials></Investigator><Investigator 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ValidYN="Y"><LastName>Eagle</LastName><ForeName>Kim</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Granger</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kennelly</LastName><ForeName>Brian</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gore</LastName><ForeName>Joel</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rubenstein</LastName><ForeName>Joel</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Moran</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kern</LastName><ForeName>Leslie</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hassett</LastName><ForeName>M Alycia</ForeName><Initials>MA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zidar</LastName><ForeName>James</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Moran</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hubbard</LastName><ForeName>Bradley</ForeName><Initials>B</Initials></Investigator></InvestigatorList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>09</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>12</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>12</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>1</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>1</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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